speaker
Zachary Rapp
Co-Founder & Chief Executive Officer · Sigma Genetics
Zachary Rapp is the Chief Executive Officer and Co-Founder at Sigma Genetics, bringing over 14 years of experience guiding disruptive, science-centric biotechnology products from discovery through preclinical development. At Sigma Genetics, Zach is leading the development of Magnetoporation™, a scalable, non-viral gene delivery platform, demonstrating its efficacy for CAR T cell engineering and intracellular genetic modifications. Under his leadership, Sigma Genetics has advanced multiple CAR T programs targeting hematologic malignancies and solid tumors in collaboration with Seattle Children’s Research Institute, Seattle Children's Therapeutics, and City of Hope, leveraging their GMP manufacturing capabilities, clinical expertise, and established regulatory pathways. Additionally, Zach is spearheading collaborations with the United States Air Force (USAF) and Bloodworks Northwest to develop lyophilized RBCs and blood products aimed at enhancing military and global blood supplies for combat trauma, solid tumor, and immunocompromised patients.
Prior to Sigma Genetics, Zach served as the first hire and Director at Altoida Inc., pioneering a smartphone-based augmented reality technology utilizing readily available sensors to predict and monitor neurodegenerative diseases. In this role, he led business development efforts, secured strategic partnerships with global biopharmaceutical companies, advanced clinical adoption at leading medical centers, and successfully raised venture capital funding.
Zach’s earlier experience includes his tenure as a consultant at Pharmagellan LLC, where he conducted detailed competitive and financial analyses of biotechnology products, portfolios, and companies. His scientific training at Columbia University and the Icahn School of Medicine at Mount Sinai focused on oncology and genetics, notably co-discovering and characterizing the secreted tumor suppressor PTEN-Long, a potent PI3K pathway inhibitor demonstrating robust tumor regression in preclinical models. This seminal research was published in Science, protected by multiple patents, selected by the National Cancer Institute’s Experimental Therapeutics program, and subsequently acquired for clinical development.
He has authored several scientific and economic publications featured in leading journals such as Science, Cell, Surgery, and Forbes, demonstrating his proficiency in bridging scientific innovation with impactful industry insights.